Heart Failure (HF) is a devastating disease that affects more than 12.1 million HF patients and 3.0 million incident HF patients over 25 years old in China. Both prevalence and incidence increased with increasing age (0.57%, 3.86%, and 7.55% for prevalence and 158, 892, and 1655 per 100,000 person-years for incidence among people who were 25, 65, and 80 years of age, respectively). However, the WHO has discovered a 29% increase in total heart disease deaths in Pakistan in only three years, totaling around 406,870 each year. and for 300,000 Australians and 11 million people in the US and Europe, with an incidence of 1.1 million new cases per year. Furthermore, HF incidence is expected to rise by 40% by 2040 based on current growth rates.According to the US National Institutes of Health (NIH), 100,000 patients could immediately benefit from a ventricular assist device (VAD) or total artificial heart (TAH), and the European market is similarly sized. Without intervention, patients with severe HF have a bleak outlook. For these patients, drug therapy is a limited, relatively ineffective option. Although a heart transplant would meet their needs, only 4,000 donor hearts are available globally each year.
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